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CD137 IgG1 Fc, Fusion Protein (4-1BB, TNFRSF9, 4-1BB ligand receptor, CD137, CD137 antigen, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell antigen ILA, Tumor necrosis factor receptor superfamily member 9 precursor) (Biotin)

Cat no: C2548-39R

CD137 IgG1 Fc, Fusion Protein (4-1BB, TNFRSF9, 4-1BB ligand receptor, CD137, CD137 antigen, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell antigen ILA, Tumor necrosis factor receptor superfamily member 9 precursor) (Biotin)

Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation (3). CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily (1,2). CD137 appears to be important for T cell proliferation and survival (4).\n\nFunctional Application: CD137 Ig fusion protein blocks binding of anti-human CD137 to activated CEM human tumor cells and also binds to CD137 Ligand on Raji cells.

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SPECIFICATIONS

Catalog Number

C2548-39R

Size

25ug

Applications

ELISA, FC

Conjugates

Biotin

Form

Supplied as a liquid in FBS, 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.04% NaN3.

Purity

Purified by Protein A affinity chromatography.

References

(1) M.R. Alderson, et al, (1994) Eur J Immunol 24: 2219-2227. \n(2) H.J. Gruss, and S.K. Dower, (1995) Blood 85: 3378-3404. \n(3) B.A. Garni-Wagner, et al, (1996) Cellular Immunol 169: 91-98. \n(4) H. Schwarz, et al, (1996) Blood 87: 2839-2845

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