CD137L, Soluble, Recombinant, Human (4-1BBL, TNFSF9)

Cat no: 044651

Supplier: United States Biological

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Additional Information

The CD137 ligand (CD137L; 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response. Sequence: The extracellular domain of human CD137L (aa 49-254) is fused at the N-terminus to a FLAG(R)-tag. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 1 year after receipt when stored at -20 degrees C. Working aliquots are stable for up to 3 months when stored at -20 degrees C.

Catalogue number:	044651
Size:	50ug
Form:	Supplied as a lyophilized powder from a 0.2um-filtered solution in PBS, pH 7.2.
Purity:	>95% (SDS-PAGE)
Alternative names:	4-1BBL, TNFSF9
References:	Product Reference: ?Production of recombinant human trimeric CD137L (4-1BBL). Cross-linking is essential to its T cell costimulationactivity: C. Rabu, et al.; J. Biol. Chem. 280, 41472 (2005) ?
Additional info:	Binds to human CD137.

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CD137L, Soluble, Recombinant, Human (4-1BBL, TNFSF9)

Cat no: 044651

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