CD152 IgG2a Fc, Fusion Protein (CTLA4, Cytolytic T-lymphocyte-associated Antigen 4) (FITC)

Immune response mediated by T cells can be characterized to functionally proceed as follows: antigen recognition by the T cell receptor, activation through costimulation, effector activities to eliminate antigen and finally down regulation. Human CD152 is a cell surface glycoprotein expressed at low levels on activated T cells. CD152 is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2) and appears to function as a negative regulator of T cell activation. Therefore, CD152 may be an important player in down regulating T cell mediated immune responses. The CD152 Ig fusion protein has biological activity and binds with high affinity to human or mouse CD80 (B7-1) and CD86 (B7-2). CD152 Ig will block the binding of anti-CD80 (B7-1) and anti-CD86 (B7-2) monoclonal antibodies.\n\nFunctional Application: CD152 Ig binds with high affinity to human or mouse CD80 (B7-1) and CD86 (B7-2)(4, 5).

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

C2548-83V2

Size

50Tests

Applications

ELISA, FC

Form

Supplied as a liquid in 50mM sodium phosphate pH 7.5, 100mM potassium chloride, 150mM sodium chloride, 5% glycerol, 0.2% BSA, 0.04% sodium azide. Labeled with FITC.

Purity

Purified by Protein A affinity chromatography.

References

1. T. Lindsten, et al, (1993) J Immunol 151: 3489-3499. \n2. T.L. Walunas, et al, (1994) Immunity 1: 405-413.\n3. N.J. Karandikar, et al, (1996) J Exp Med 184: 783-788. \n4. A.H. Cross, et al, (1995) J Clin Invest 95 : 2783-2789. \n5. P.A. Morton,et al, (1996) J Immunol 156: 1047-1054. \n6. Martin K. Oaks and Karen M. Hallett, (2000) J Immunol 164: 5015-5018