CD1C, CT (CD1C, T-cell surface glycoprotein CD1c, CD1c) (Biotin)

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

033470-Biotin

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Biotin.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Van Brussel, I., et al. J. Immunol. Methods 362 (1-2), 168-175 (2010) :\nDavila, S., et al. Genes Immun. 11(3):232-238(2010)\nGarzon, D., et al. Mol. Immunol. 47 (2-3), 253-260 (2009) :\nVan Rhijn, I., et al. J. Exp. Med. 206(6):1409-1422(2009)\nKaser, A., et al. Eur. J. Immunol. 38(8):2351-2359(2008)

Additional Info

Human

Alternative Names

CD1C, T-cell surface glycoprotein CD1c, CD1c