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CD24 (GPI-linked surface Mucin, Nectadrin)

Cat no: C2275-05A

CD24 (GPI-linked surface Mucin, Nectadrin)

CD24, also known as heat stable antigen, is a phosphatidylinositol-linked cell surface glycoprotein that is expressed at all stages of B cell development and on most thymocytes.1-3 The absence of expression from mature T cells is closely associated with their maturation from CD4+CD8+CD24+ thymocytes to either CD4+CD8-CD24- or CD4-CD8+CD24- T cells. CD24 is also present on mouse granulocytes, monocytes, Langerhans cells and erythrocytes.4-6 Its ligand is P-selectin (CD62P).7 CD24 may play a role in regulation of B cell proliferation and differentiation, and it has been proposed that heat stable antigen promotes homotypic adhesion between B lymphocytes.1-3 Can be used to inhibit B-cell differentiation.\n\nApplications:\n

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SPECIFICATIONS

Catalog Number

C2275-05A

Size

500ug

Applications

FC, IHC, IP

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a liquid in 100mM borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added.

P Type

Mab

Purity

Purified

Isotype

IgG2a,k

References

1. Bruce, J., F.W. Symington, T.J. McKearn, and J. Sprent. 1981. J. Immunol. 127:2496.\n2. Alterman, L.A., I.N. Crispe, and C. Kinnon. 1990. Eur. J. Immunol. 20:1597.\n3. Davidson, W.F., T.M. Chused, and H.C. Morse. 1981. Immunogenetics 13:421.\n4. Rougon, G., L.A. Alterman, K. Dennis, X.J. Guo, and C. Kinnon. 1991. Eur. J. Immunol. 21:1397.\n5. Wilson, A., L.M. Day, R. Scollay, and K. Shortman. 1984. Immnol. Rev. 82:79.\n6. Shortman, K., A. Wilson, M. Egerton, M. Pearse, and R. Scollay. 1988. Cell. Immunol. 117:312.\n7. Aigner, S., M. Ruppert, M. Hubbe, M. Sammar, Z. Sthoeger, E. C. Butcher, D. Vestweber, and P. Altevogt. 1995. International Immunology 7:1557.

Additional Info

Recognizes mouse CD24; Mr 95kD.

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