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Products CD25 Monoclonal PE Antibody (Clone 143-13)
| Catalogue number: | 10339 |
| Hosts: | Mouse |
| Applications: | Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| P type: | Antibodies |
| Shipping temp: | 4 |
| Storage temp: | 4 |
| Additional info: | Interleukin-2 (IL-2) elicits its effects by binding to a multi-subunit cell-surface receptor that is inducible by various mitogens. The highest affinity for IL-2 is achieved when all 3 subunits (IL-2R(alpha) or CD25, IL-2R(beta) or CD122, and IL-2R(gamma) or CD132) are expressed together forming a heterotrimeric complex. CD25 is inducible in T-cells by antigen, mitogen or antibodies bound to the T-cell receptor CD3. Binding of IL-2 to IL-2R on NK cells results in their conversion to LAK cells, which release several other cytokines (TNF, INF-(gamma), and GM-CSF). Activated T-cells will respond to IL-2 by proliferating and secreting cytokines and cytolytic molecules. Activated B cells will proliferate and secrete antibodies. |
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