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CD25 Monoclonal PE Antibody (Clone 143-13)

Cat no: 10339

CD25 Monoclonal PE Antibody (Clone 143-13)

Host: mouse, clone 143-13 . Cross Reactivity: (+) human CD25; other species not tested . Applications: (+) FC, ICC, and IHC (frozen sections); (-) WB

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SPECIFICATIONS

Catalog Number

10339

Applications

FC, ICC, IHC, WB

Hosts

Mouse

Form

1 ea

P Type

Antibodies

Weight

0

Storage Temp

4

Shipping Temp

4

Additional Info

Interleukin-2 (IL-2) elicits its effects by binding to a multi-subunit cell-surface receptor that is inducible by various mitogens. The highest affinity for IL-2 is achieved when all 3 subunits (IL-2R(alpha) or CD25, IL-2R(beta) or CD122, and IL-2R(gamma) or CD132) are expressed together forming a heterotrimeric complex. CD25 is inducible in T-cells by antigen, mitogen or antibodies bound to the T-cell receptor CD3. Binding of IL-2 to IL-2R on NK cells results in their conversion to LAK cells, which release several other cytokines (TNF, INF-(gamma), and GM-CSF). Activated T-cells will respond to IL-2 by proliferating and secreting cytokines and cytolytic molecules. Activated B cells will proliferate and secrete antibodies.

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