CD27, Recombinant, Human, aa21-191, His-Tag (CD27 Antigen, S152, T14, TNFRSF7, Tp55)

TNFRSF7, also known as CD27, is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. \n\nSource:\nRecombinant protein corresponding to aa21-191 from human CD27 at N-terminal, fused to His-tag expressed in E.coli. \n\nMolecular Weight: \n~21.8kD (196aa)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGSHM\nHCNSGLLVRN CTITANAECA CRNGWQCRDK ECTECDPLPN PSLTARSSQA LSPHPQPTHL PYVSEMLEAR TAGHMQTLAD FRQLPARTLS TPAPK SCPERHYWAQ GKLCCQMCEP GTFLVKDCDQ HRKAAQCDPC IPGVSFSPDH HTRPHCESCR\nTHWPPQRSLC SSDFIR\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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