Home  >  Products  >  CD273 (Programmed Cell Death 1 Ligand 2, PD-1 Ligand 2, PD-L2, PDCD1 Ligand 2, Programmed Death Ligand 2, Butyrophilin B7-DC, B7-DC, PDCD1LG2, B7DC, PDCD1L2, PDL2)
CD273 (Programmed Cell Death 1 Ligand 2, PD-1 Ligand 2, PD-L2, PDCD1 Ligand 2, Programmed Death Ligand 2, Butyrophilin B7-DC, B7-DC, PDCD1LG2, B7DC, PDCD1L2, PDL2)

CD273 (Programmed Cell Death 1 Ligand 2, PD-1 Ligand 2, PD-L2, PDCD1 Ligand 2, Programmed Death Ligand 2, Butyrophilin B7-DC, B7-DC, PDCD1LG2, B7DC, PDCD1L2, PDL2)

Cat no: C2549-21K

Supplier: United States Biological
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Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PDCD-1 that mediate inhibitory signals from the APC. PDCD-1 can bind two different but related ligands, PDL-1 and PDL-2, both of which are thought to act as a negative regulator of T cell activation. However, it has been suggested that PDL-2 can act to stimulate an immunogenic response through an alternative receptor from PDCD-1. At least three isoforms of PDL-2 are known to exist; this antibody is specific to the larger isoform. PDL-2 antibody has no cross-reactivity to PDL-2. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Raji cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2549-21K
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
References: 1. Holling TM, et al (2004) Hum. Immunol. 65:282-90. 2. Ishida Y, et al (1992) EMBO J. 11:3887-95. 3. LaGier J, et al (2006) Hum. Immunol. 67:568-78. 4. Zhang Y, et al (2006) Proc. Natl. Acad. Sci. USA. 103:11695-700. 5. Liu X, et al (2003) J. Exp. Med. 197;1721-30.
Additional info: Recognizes human PDL-2. Species Crossreactivity: mouse and rat.

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