CD36, Low Endotoxin (gpIIIb, gpIV, Thrombospondin Receptor)

The CD36 molecule is type B scavenger receptor, which binds to multiple ligands including thrombospondin, anionic phospholipids, oxidized low density lipoproteins and long chain fatty acids. CD36 has diverse functions and is reported to play a role in innate immunity, platelet adhesion/aggregation and long chain fatty acid transport. The CD36 molecule also directly mediates cytoadhesion of erythrocytes infected with Plasmodium Falciparum, and may be involved in the development of atherosclerotic lesions and the formation of foam cells.\n\nApplications: \nSuitable for use in Flow Cytometry, Immunofluorescence, Western Blot, Immunoprecipitation and Functional applications. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: 10ul labels 1x10e6 cells in 100ul.\nOptimal dilutions to be determined by the researcher.\n\nHybridoma: \nY3Ag 1.2.3 myeloma cells with spleen cells from DA rats \n\nRecommended Negative Control:\nI1904-82D1: IgG2a, Rat Negative Control\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C2388-03D

Size

500ug

Applications

FC, IF, IP, WB

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a liquid in PBS, pH 7.4. No preservatives added.

P Type

Mab

Purity

Purified by Protein G affinity chromatography. Endotoxin: (same/less than)0.01EU/ug.

Isotype

IgG2a

References

1. Helming, L. M.et al. (2009) The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion. J. Cell Science. 122: 453-459. 2. Mwaikambo, B.R. et al. (2009) Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms.J Biol Chem. 284: 26695-707. 3. Yang, C.N. et al. (2011) Mechanism mediating oligomeric Ab clearance by na

Additional Info

Recognizes mouse CD36, an 85kD transmembrane glycoprotein which is primarily expressed on platelets, monocytes/macrophages, smooth muscle and endothelial cells. Inhibits IL-4 induced thioglycollate-elicited peritoneal macrophage fusion and significantly blocks IL-4/GM-CSF-induced bone-marrorw derived macrophage fusion.