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Products CD45 Monoclonal Antibody (Clone BRA-55)
| Catalogue number: | 10004597 |
| Hosts: | Mouse |
| Applications: | Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human CD45 |
| P type: | Antibodies |
| Shipping temp: | 4 |
| Storage temp: | 4 |
| Additional info: | CD45 is a type I transmembrane glycoprotein, common leukocyte antigen. As a result of alternative splicing between exons 4, 5, and 6, which encode A, B, and C determinants respectively, CD45 is expressed as four isoforms: CD45RA (Mr = 220 kDa), CD45RB (Mr = 210 kDa), CD45RC (Mr = 200 kDa), and CD45RO (Mr = 180 kDa). The highest level of CD45 expression is observed on lymphocytes. Resting T cells and NK cells express CD45RA and CD45RB. Activated T cells, memory T cells, monocytes, granulocytes, and dendritic cells express CD45RO and CD45RC; however B cells only express CD45RA. CD45 monoclonal antibodies are widely used for differential diagnosis of lymphoid malignancies. |
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