CD51, CD61 (Integrin alpha-V, Vitronectin Receptor Subunit alpham ITGAV, MSK8, VNRA/ Integrin beta-3, Platelet Membrane Glycoprotein IIIa, GPIIIa, ITGB3, GP3A)

CD51/CD61 is an integrin complex known as aVb3. It is expressed at high levels on osteoclasts, endothelial cells, and melanoma cells and at low levels on platelets and macrophages. CD51 is a heterodimer composed of disulfide-linked 125 kD and 24 kD proteins. CD61 is also a member of the integrin family known as gpIIIa or b3 integrin. It is a 110 kD common b subunit of CD51/CD61 or CD41/CD61 complex. CD51/CD61, also known as the vitronectin receptor, mediates the binding of platelets to immobilized vitronectin without prior activation. Other ligands include RGD-containing proteins such as fibrinogen, fibronectin, von Willebrand factor (vWf), laminin, thrombospondin and the neural adhesion molecule L1. CD51/CD61 also mediates cell-cell adhesion via interaction with CD31. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins, including matrix components. \n\nApplications:\nSuitable for use in Flow Cytometry, Immunoprecipitation, Immunohistochemistry and Immunofluorescence. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C2405-17U

Size

100ug

Applications

FC, IF, IHC, IP

Hosts

Mouse

Reactivities

Hum, Ch/Bird, Rabbit

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Mab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG1,k

References

1. Knapp, W., B et al. 1989. Leucocyte Typing IV, Oxford University Press. New York. 2. Schlossman, S., et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. 3. Horton, M., et al. 1991. Exp. Cell Res. 195:368. 4. Takahashi, R., et al. 1999. Blood 93:1951. 5. Davies, J., et al. 1989. J. Cell Biol. 109:1817. (IHC, IF, IP) 6. Deregibus, M.C.., et al. 2007. Blood. doi:10.1182/blood-2007-03-078709 7. Barau, A., et al. 2010. J. Ultrasound Med. 29:173. 8. Davies, J., et al. 1989. J. Cell Biol. 109:1817. 9. Nesbitt, S., et al. 1993. J. Biol. Chem. 268:16737.

Additional Info

Recognizes human CD51 and CD61. Species Crossreactivity: rabbit, chicken.