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CD51 (Integrin alphaV, Vitronectin alpha Subunit Receptor, VNR) (FITC)

Cat no: C2405-11K

CD51 (Integrin alphaV, Vitronectin alpha Subunit Receptor, VNR) (FITC)

CD51 represents the 150kD integrin alphaV chain that associates with integrin beta3 (CD61) to form the CD51/CD61 vitronectin receptor on endothelial cells, certain activated leukocytes, NK cells, macrophages, neutrophils and platelets. CD51 is the most promiscuous integrin a subunit; it can form heterodimers with the beta1 (CD29), beta3 (CD61), beta5, beta6 and beta8 subunits in various tissues. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins, including matrix components. It also mediates leukocyte-endothelial cell adhesion via interaction with CD31.1-4\n\nApplications:\n

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SPECIFICATIONS

Catalog Number

C2405-11K

Size

100Tests

Applications

FC, IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Conjugated to FITC.

P Type

Mab

Purity

Purified

Isotype

IgG1

References

1. Knapp, W., B. Dorken, W.R. GIlks, E.P. Rieber, R.E. Schmidt, H. Stein, A.E.G.K. Von dem Borne, eds. 1989. Leukocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, Oxford.\n2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD51 Section, Academic Press, New York, p. 271.\n3. Keiffer, N., and D.R. Phillips. 1990. Annu. Rev. Cell. Biol. 6:329.\n4. Ginsberg, M.H., D. Xiaoping, T.E. O

Additional Info

Recognizes human CD51.

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