Home  >  Products  >  CD52 (CD52 Antigen, CD52 Molecule, CDw52, Cambridge Pathology 1 Antigen, CAMPATH 1, CAMPATH-1 Antigen, Epididymal Secretory Protein E5, HE5)
CD52 (CD52 Antigen, CD52 Molecule, CDw52, Cambridge Pathology 1 Antigen, CAMPATH 1, CAMPATH-1 Antigen, Epididymal Secretory Protein E5, HE5)

CD52 (CD52 Antigen, CD52 Molecule, CDw52, Cambridge Pathology 1 Antigen, CAMPATH 1, CAMPATH-1 Antigen, Epididymal Secretory Protein E5, HE5)

Cat no: C2407-50K1

Supplier: United States Biological
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The CD52 antigen is also known as CAMPATH 1. It is a remarkably small peptide that is heavily glycosylated. It is attached to the cell surface membrane via a GPI link. The apparent molecular mass of the antigen on SDS-PAGE is 25-29kD. CD52 is expressed at high density by lymphocytes, monocytes, eosinophils, thymocytes and macrophages. It is expressed by most lymphoid derived malignancies, although expression on myeloma cells is variable. Applications: Suitable for use in Cytotoxicity Assays, ELISA, Flow Cytometry, Immunohistochemistry (frozen, resin, and paraffin), Immunoprecipitation, and Western Blot. Other applications not tested. Recommended Dilution: Flow cytometry: 1:50-1:100. Use 10ul of the suggested working dilution to label 1 x 10e6 cells in 100ul. Cytotoxic Assays: 50ug/ml (Use human serum as complement source) Optimal dilutions to be determined by the researcher. Recommended Positive Control Tissue: Tonsil Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2407-50K1
Reactivities: Human, Non-Human Primate
Hosts: Rat
Applications: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 500ug
Form: Supplied as a liquid in PBS. No preservative added.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein A affinity chromatography.
References: 1. Hale, G. et al. (1998) Improving the Outcome of Bone Marow Transplantation by using CD52 Monoclonal Antibodies to prevent graft-versus-host disease and graft rejection. Blood 92: 4581-4590 2. Salisbury, J.R. et al. (1994) Immunohistochemical analysis of CDw52 antigen expression in non-hodgkins lymphomas. J. Clin. Path. 47: 313 - 317
Additional info: Recognizes human CD52. Species Crossreactivity: Rhesus monkey.

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