CD56, Recombinant, Human (NCAM-1, Neural Cell Adhesion Molecule)

Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kD isoform (1102-1150 a.a.) is the basic molecule which is glycosylated or sialylated to produce the mature species. NCAM (CD56) is reported to express on most neuroectodermal derived cell lines, tissues, and neoplasms such as retinoblastoma, medullblastoma, astrocytoma, and neuroblastoma. It is also expressed on some mesodermally derived tumors such as rhabdomyosarcoma and also on natural killer cells.\n\nApplications:\n

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SPECIFICATIONS

Catalog Number

C2410-63H

Size

2ug

Form

Supplied as a liquid in 50mM Tris-acetate, pH 7.5, 1mM EDTA and 20% glycerol.

Purity

On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 48kD

References

1. Non-CD34(+) Cells, Especially CD8(+) Cytotoxic T Cells and CD56(+) Natural Killer Cells, Rather Than CD34 Cells, Predict Early Engraftment and Better Transplantation Outcomes in Patients with Hematologic Malignancies after Allogeneic Peripheral Stem Cell Transplantation.\n\nBiol Blood Marrow Transplant 2006 Jul;12(7):719-28\n\n2. CD56+ Lymphoproliferative Disorders of the Skin-A Clinicopathologic Analysis of 34 Cases: A Multicenter Study From EORTC Cutaneous Lymphoma Project.\n\nAm J Dermatopathol 2006 Jun;28(3):234\n\n3. Role for interleukin-6 and insulin-like growth factor-I via PI3-K/Akt pathway in the proliferation of CD56- and CD56+ multiple myeloma cells.\n\nExp Hematol 2006 Jun;34(6):736-44\n\n4. NKG2A and CD56 are coexpressed on activated TH2 but not TH1 lymphocytes.\n\nHum Immunol 2005 Dec;66(12):1223-34\n\n5. Blastic natural killer (NK) cell leukemia (agranular CD4+CD56+ leukemia).\n\nAnn Clin Lab Sci 2006 Spring;36(2):212-5\n\n6. Uterine (CD56+) natural killer cells recruitment: association with decidual reaction rather than embryo implantation.\n\nAm J Reprod Immunol 2006 May;55(5):369-77