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CD58 (Lymphocyte Function-associated Antigen 3, Ag3, Surface Glycoprotein LFA-3, LFA3)

CD58 (Lymphocyte Function-associated Antigen 3, Ag3, Surface Glycoprotein LFA-3, LFA3)

Cat no: C2412-05H

Supplier: United States Biological
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CD58, also known as lymphocyte function-associated antigen 3 (LFA-3) is a 45-70 kD cell surface protein that is a member of the immunoglobulin superfamily. Alternative splicing of CD58 gives rise to transmembrane and glycosylphosphatidylinositol (GPI)-anchored forms on cell surface. CD58 is xpressed on both hematopoietic and non-hematopoietic cells including B cells, T cells, monocytes, erythrocytes, endothelial cells, epithelial cells, and fibroblasts. High levels are observed on memory T cells and dendritic cells. CD58 expressed on antigen presenting cells and target cells enhances T cell recognition via the binding of its cognate ligand, CD2, on the T cell surface. Applications: Suitable for use in Flow Cytometry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2412-05H
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Springer, T.A., et al. 1987. Annu. Rev. Immunol. 5:223. 2. Dustin, M.L., et al. 1987. Nature 329:846. 3. Arulanandam, A.R., et al. 1994. J. Exp. Med. 180:1861. 4. Sanders, M.E., et al. 1988. J. Immunol. 140:1401. 5. Sanchez-Madrid, F., et al.. 1982. P. Natl. Acad. Sci. USA 79:7489. 6. Le, P.T., et al. 1990. J. Immunol. 144:4541.
Additional info: Recognizes human CD58.

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