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CD74 (Invariant chain, P33, CLIP, DHLAG, HLADG, La-gamma, INVG34)

Cat no: 145425

CD74 (Invariant chain, P33, CLIP, DHLAG, HLADG, La-gamma, INVG34)

CD74, also known as Invariant chain (Ii) and p33, is a type 2 transmembrane glycoprotein that plays an important role in adaptive immunity, inflammation, and cancer (1). Mature mouse CD74 consists of a 29 amino acid (aa) cytoplasmic domain, a 29aa transmembrane segment, and a 224aa extracellular domain (ECD) that contains one thyroglobulin type 1 domain (2). Alternative splicing generates a short isoform that lacks the thyroglobulin domain (2). Within the ECD, mouse CD74 shares 75% and 88% aa sequence identity with human and rat CD74, respectively. CD74 functions as a chaperone for MHC class II molecules on antigen presenting cells and undergoes progressive proteolysis during class II trafficking and antigenic peptide loading (3). Full length CD74 assembles into trimers which then associate with class II molecules in nonameric complexes on the cell surface (4, 5). CD74 also associates with CD44 and binds with high affinity to the cytokine MIF, leading to inflammatory leukocyte responses, protection from tissue fibrosis, B cell proliferative and survival signaling, and the up

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SPECIFICATIONS

Catalog Number

145425

Size

100ug

Applications

ELISA, FC

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a lyophilized powder in PBS, Trehalose. Reconstitute in sterile PBS.

P Type

Mab

Purity

Purified by Protein A or G affinity chromatography.

Isotype

IgG1

Additional Info

Recognizes mouse CD74 in direct ELISAs.

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