CDK5R1(p35), NT (Cyclin-dependent kinase 5 activator 1 [Precursor], CDK5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, Tau protein kinase II 23kD subunit, p23, TPKII regulatory subunit, Cyclin-dependent kinase 5 activator 1, p35, Cyclin-dep

p35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.\n\nApplications:\nSuitable for use in Immunohistochemistry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nImmunohistochemistry: 1:10-50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze horseradish peroxidase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

033670-HRP

Size

200ul

Applications

ELISA, IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free). Conjugated to HRP.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

Lin,S., FEBS Lett. 582 (8), 1197-1202 (2008)\nSen,A., Neuroreport 18 (5), 511-516 (2007)\nMitsios,N., Brain Pathol. 17 (1), 11-23 (2007)

Additional Info

Human

Alternative Names

Cyclin-dependent kinase 5 activator 1 [Precursor], CDK5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, Tau protein kinase II 23kD subunit, p23, TPKII regulatory subunit, Cyclin-dependent kinase 5 activator 1, p35, Cyclin-dependent kinase 5 activator 1, p25, CDK5R1, CDK5R, NCK5A