CEACAM 1 (Carcinoembryonic Antigen Related Cell Adhesion Molecule, BGP)

CEACAM1 (BGP) belongs to the carcinoembryonic antigen \n(CEA) gene family. It is expressed on cells of epithelial and myeloid origin. CEACAM1 expression is downregulated in many tumors indicating a tumor-suppressive function. The antitumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of antiangiogenic molecules from the cells. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the iimmunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While the N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAM.\n\nApplications:\nSuitable for use in Flow Cytometry, ELISA and Immunohistochemistry. It is expected that the antibody will be suited for all applications where recognition of the native protein is required. Other applications not tested. \n\nRecommended Dilution: \nELISA: 1:200-1:400\nImmunohistochemistry (Frozen): 10ug/ml \nFlow Cytometry: 1.2ug/10e6 cells\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C2589-53

Size

50ug

Applications

ELISA, FC, IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

Additional Info

Recognizes human CEACAM1(biliary glycoprotein I, BGP,CD66a) transiently expressed on the cell surface of transfected BOSC cells as well as the naturally expressed protein. As the A2 domain is unique to CEACAM1, C2589-53 can be used to distinguish CEACAM1 from all other CEACAM.