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Chemokine-Like Receptor 1 Polyclonal Antibody

Cat no: 10325

Chemokine-Like Receptor 1 Polyclonal Antibody

Antigen: human CMKLR1 amino acids 358-371 . Host: rabbit . Cross Reactivity: (+) human, monkey, mouse, and rat CMKLR1 . Application(s): FC, ICC, and WB . CMKLR1 is a GPCR relevant to the cellular chemotaxis of dendritic cells and macrophages. Chemerin, or TIG2, and Resolvin E1 are ligands for this receptor.

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SPECIFICATIONS

Catalog Number

10325

Applications

FC, ICC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

human CMKLR1 amino acids 358-371 (NERTSMNERETGML)

Storage Temp

-20

Shipping Temp

-20

Additional Info

Chemokine-Like Receptor 1 (CMKLR1) is a G protein-coupled receptor relevant to the cellular chemotaxis of dendritic cells and macrophages. This receptor is also expressed in brain, liver, lung, and kidney tissues. Chemerin, or TIG2, has been identified as the natural ligand for this receptor. Resolvin E1 has also been identified as a ligand for CMKLR1; acting to dampen cellular responses to inflammation. Chemerin is an 18 kDa protein that plays a role in immunity, inflammation, chemotaxis, and has been identified as an adipokine. Human CMKLR1 shares 80% sequence homology with its mouse ortholog. The human receptor exists in two isoforms, differing only by two amino acids due to a premature stop codon. Isoform one has 363 amino acids and an expected molecular weight of 42.3 kDa. Cayman

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