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Chk2, phosphorylated (Ser516) (Serine/Threonine-protein Kinase Chk2, Cds1, CHK2, RAD53)

Chk2, phosphorylated (Ser516) (Serine/Threonine-protein Kinase Chk2, Cds1, CHK2, RAD53)

Cat no: C4201-05K

Supplier: United States Biological
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The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and PID:MTA2, were recently discovered. The checkpoint kinase Chk2 is the mammalian homologue of yeast Cds1:Rad53. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53. Chk2 serves as ATM downstream effector to mediate activation of p53. Chk2 also phosphorylates and activates BRCA1, the product of a tumor suppressor gene that is mutated in breast and ovarian cancer. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control: HeLa cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C4201-05K
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Lee, JS. et al. Nature. 404:201-214 (2000).
Additional info: Recognizes human Chk2 phosphorylated at Ser516.

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