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CHMP2B, Recombinant, Human, aa1-213, His-tag (Chromatin modifying protein 2B)

Cat no: C5039-01L

CHMP2B, Recombinant, Human, aa1-213, His-tag (Chromatin modifying protein 2B)

CHMP2B belongs to the vacuolar sorting protein family. It is a component of the ESCRT-III complex. This complex is crucial for sorting endosomal articles into multivesicular bodies (MVBs), and are also required for the formation of these bodies. CHMP2B widely expressed in brain, heart, skeletal muscle, small intestine, pancreas, lung, placenta and leukocytes. \n\nSource:\nRecombinant corresponding to aa1-213 from human Chromatin modifying protein 2B, fused with His-tag at N-terminus, expressed in E.coli.\n\nAA sequence:\nMGSSHHHHHH SSGLVPRGSH MASLFKKKTV DDVIKEQNRE LRGTQRAIIR DRAALEKQEK QLELEIKKMA KIGNKEACKV LAKQLVHLRK QKTRTFAVSS KVTSMSTQTK VMNSQMKMAG AMSTTAKTMQ AVNKKMDPQK TLQTMQNFQK ENMKMEMTEE MINDTLDDIF DGSDDEEESQ DIVNQVLDEI GIEISGKMAK APSAARSLPS ASTSKATISD EEIERQLKAL GVD\n\nMolecular Weight: \n~26.1kD (233aa), confirmed by MALDI-TOF \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C5039-01L

Size

100ug

Form

Supplied as a liquid in 20mM Tris-HCl, pH 8, 1mM DTT, 0.1M sodium chloride, 10% glycerol.

Purity

~90% (SDS-PAGE)

References

Rizzu P., et al. (2006) Am J Med Genet B Neuropsychiatr Genet. 141B(8):944-6. Stuchell-Brereton MD., et al. (2007) Nature. 449(7163):740-4.

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