Home  >  Products  >  Clusterin (Clusterin Precursor, CLU, AAG4, Apolipoprotein J, APOJ, Apo-J, CLI, Complement-associated Protein SP-40, Complement Cytolysis Inhibitor, KUB1, MGC24903, NA1/NA2, SGP2, SGP-2, SP-40, Testosterone-repressed Prostate Message 2, TRPM2, TRPM-2)
Clusterin (Clusterin Precursor, CLU, AAG4, Apolipoprotein J, APOJ, Apo-J, CLI, Complement-associated Protein SP-40, Complement Cytolysis Inhibitor, KUB1, MGC24903, NA1/NA2, SGP2, SGP-2, SP-40, Testosterone-repressed Prostate Message 2, TRPM2, TRPM-2)

Clusterin (Clusterin Precursor, CLU, AAG4, Apolipoprotein J, APOJ, Apo-J, CLI, Complement-associated Protein SP-40, Complement Cytolysis Inhibitor, KUB1, MGC24903, NA1/NA2, SGP2, SGP-2, SP-40, Testosterone-repressed Prostate Message 2, TRPM2, TRPM-2)

Cat no: C5870-01G

Supplier: United States Biological
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Clusterin is an ubiquitously expressed protein of two 40-kD chains, alpha and beta, covalently joined by disulfide bonds. It exists in two forms; a pro-apoptotic form localized to the nucleus and a pro-survival secreted form. Both are thought to be involved in DNA repair and cell cycle regulation. The secreted form is thought to inhibit apoptotic signalling by BAX, Clusterin suppression can sensitise cells to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancers and squamous cell carcinomas. Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimer
Catalogue number: C5870-01G
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in borate buffered saline, pH 8.4, 0.02% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
Alternative names: Aging-associated Protein 4
References: 1. Kumita, J. et al. (2007) The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species. J. Mol. Biol. 369:157-167.2. Shannan, B. et al. (2006) 2. (2006). Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control. J. Mol. Histol. 37:183-188.
Additional info: Recognizes human CLUSTERIN.

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