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Complement C3, C3d (Complement C3d Fragment, Complement Component C3d, C3/C3d, Complement Component 3, Complement Factor 3, CPAMD1)

Complement C3, C3d (Complement C3d Fragment, Complement Component C3d, C3/C3d, Complement Component 3, Complement Factor 3, CPAMD1)

Cat no: C7850-14V

Supplier: United States Biological
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Human complement component 3d (C3d) is a 33kD polypeptide fragment generated over the course of complement activation where complement 3 (C3) convertases cleave C3 to C3b, which is further degraded into iC3b and C3dg/C3d. C3d is involved in the regulation of many aspects of the immune response, including antigen processing and presentation. The C3d/antigen complex mediates B cell activation by simultaneously binding antigen-specific surface bound immunoglobulin and CD21, lowering the complement activation threshold. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation. Applications: Suitable for use in ELISA and Radial Immunodiffusion. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7850-14V
Reactivities: Human
Hosts: Sheep
Applications: ELISA
Size: 1ml
Form: Supplied as a liquid in GBS, 0.1% EACA, 0.01% benzamidine, 1mM EDTA, 0.09% sodium azide
P type: Pab
Isotype: IgG
Purity: Purified by Ion Exchange chromatography.
References: 1.Luo, Y.H. et al Kidney Int, 72: 716-724 (2007)
Additional info: Recognizes human C3d. Gave a single arc in the alpha region when tested by IEP against aged human plasma (C3d) and a contiuous double arc in the alpha and beta regions when tested against fresh human plasma (C3 and C3d). Identity was confirmed by double diffusion (ouchterlony) vs human plasma and a known anti-human C3d.

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