Connexin 30, GJB6, Gap Junction Protein, beta 6, (30kDa)

Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.\n\nApplications:\nSuitable for use in ELISA. Other applications have not been tested. \n\nRecommended Dilutions: \nPeptide ELISA Titer: 1:16,000\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C7853-45

Size

100ug

Applications

ELISA

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by peptide affinity chromatography.

Isotype

IgG

References

1. Belguith H, Tlili A, Dhouib H, Ben Rebeh I, Lahmar I, Charfeddine I, Driss N, Ghorbel A, Ayadi H, Masmoudi S, Mutation in gap and tight junctions in patients with non-syndromic hearing loss. Biochemical and biophysical research communications 2009 Jul 385 (1): 1-5.

Additional Info

Recognizes Connexin 30. Species sequence homology: human, mouse, rat, bovine. Reported variants represent identical protein: NP_006774.2, NP_001103691.1, NP_001103689.1, NP_001103690.1

Alternative Names

gap junction protein, beta 6 (connexin 30), gap junction protein, beta 6, ectodermal dysplasia 2, hidrotic (Clouston syndrome), connexin 30, OTTHUMP00000176872, OTTHUMP00000176871, OTTHUMP00000176870, OTTHUMP00000018096, HED, EDH, ED2, DFNA3, CX30, gap junction protein, beta 6, 30kDa, GJB6