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Connexin 30, GJB6, Gap Junction Protein, beta 6, (30kDa)

Connexin 30, GJB6, Gap Junction Protein, beta 6, (30kDa)

Cat no: C7853-45

Supplier: United States Biological
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Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia. Applications: Suitable for use in ELISA. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:16,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7853-45
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: gap junction protein, beta 6 (connexin 30), gap junction protein, beta 6, ectodermal dysplasia 2, hidrotic (Clouston syndrome), connexin 30, OTTHUMP00000176872, OTTHUMP00000176871, OTTHUMP00000176870, OTTHUMP00000018096, HED, EDH, ED2, DFNA3, CX30, gap junction protein, beta 6, 30kDa, GJB6
References: 1. Belguith H, Tlili A, Dhouib H, Ben Rebeh I, Lahmar I, Charfeddine I, Driss N, Ghorbel A, Ayadi H, Masmoudi S, Mutation in gap and tight junctions in patients with non-syndromic hearing loss. Biochemical and biophysical research communications 2009 Jul 385 (1): 1-5.
Additional info: Recognizes Connexin 30. Species sequence homology: human, mouse, rat, bovine. Reported variants represent identical protein: NP_006774.2, NP_001103691.1, NP_001103689.1, NP_001103690.1

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