Home  >  Products  >  Cortactin (CTTN, Amplaxin, EMS1, FLJ34459, Oncogene EMS1, Src Substrate Cortactin)
Cortactin (CTTN, Amplaxin, EMS1, FLJ34459, Oncogene EMS1, Src Substrate Cortactin)

Cortactin (CTTN, Amplaxin, EMS1, FLJ34459, Oncogene EMS1, Src Substrate Cortactin)

Cat no: C7901-83J

Supplier: United States Biological
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Cortactin is a c-src substrate associated with sites of dynamic actin assembly at the leading edge of migrating cells promotes branched actin filament network formation by Arp2/3 complex. Cortactin is an F-actin-binding protein. The amino-terminal half of the protein is comprised of multiple copies of an internal, tandem 37- amino acid repeat while the carboxyl-terminal half contains a distal SH3 domain. Cortactin, present in several different cell types, is enriched in cortical structures such as membrane ruffles and lamellipodia. The properties of cortactin indicate its importance for microfilament-membrane interactions as well as transducing signals from the cell surface to the cytoskeleton. human cortactin gene is localized on chromosome 11q13. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochestry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7901-83J
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Wu, H. et al. The Journal of Cell Biology. 120:1417-1426 (1993).
Additional info: Recognizes human Cortactin. Species crossreactivity: mouse.

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