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COX 2 (Cyclooxygenase-2, Cox2, COX-2, PHS II, Prostaglandin G/H Synthase 2, PGH Synthase 2, Prostaglandin H2 Synthase 2, PGHS-2, Prostaglandin-endoperoxide Synthase 2, Ptgs2)

COX 2 (Cyclooxygenase-2, Cox2, COX-2, PHS II, Prostaglandin G/H Synthase 2, PGH Synthase 2, Prostaglandin H2 Synthase 2, PGHS-2, Prostaglandin-endoperoxide Synthase 2, Ptgs2)

Cat no: C7904-83N

Supplier: United States Biological
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The cyclo-oxygenase (Cox) enzyme catalyses the oxidation of arachidonic acid into prostaglandin H2. The enzyme is encoded by two related genes, Cox-l and Cox-2. The Cox-1 gene is constitutively and ubiquitously expressed, while the Cox-2 gene is only expressed at high levels upon induction by growth factors, cytokines and extracellular stimuli associated with cell activation. Many cell types associated with inflammation, such as monocytes, endothelial cells and fibroblasts, express the Cox2 gene upon induction. Besides there is evidence that it is expressed constitutively, however, the expression is usually low under physiological conditions. It has a role as a major mediator of inflammation and a role for prostanoid signaling in activity-dependent plasticity. It is expressed throughout the forebrain in discrete populations of neurons and is enriched in the cortex and hippocampus. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: Lung and colon carcinoma Cellular Localization: Cytoplasmic and membrane Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7904-83N
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid in 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
Alternative names: EC=1.14.99.1
References: 1. Susan et al. Biochem J 302, 723, 1994. 2. Yamagata et al. Neurom 2: 371, 1993. 3. Baber et al. Circulation 108: 896,2003.
Additional info: Recognizes rat COX2. Species Crossreactivity: mouse and human.

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