Catalogue number: | 160106 |
Hosts: | Rabbit |
Applications: | Immunocytochemistry, Immunohistochemistry, Western Blot |
Weight: | 0 |
Form: | 1 ea |
Antigen: | mouse/rat COX-2 amino acids 570-598 |
P type: | Antibodies|Cyclooxygenase |
Shipping temp: | -20 |
Storage temp: | -20 |
Additional info: | COX catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins: the conversion of arachidonic acid to prostaglandin H2. Recent discoveries of the induction of COX by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothosis that the inducible form of COX, COX-2, is responsible for the biosynthesis of prostaglandins under acute inflammatory conditions. COX-2 is a 72 kDa protein which has been cloned from a variety of species including human, mouse, rat, and sheep. |