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CrkL (Crk-like protein, v-crk sarcoma virus CT10 oncogene homolog (avian)-like)

CrkL (Crk-like protein, v-crk sarcoma virus CT10 oncogene homolog (avian)-like)

Cat no: C7925-10D

Supplier: United States Biological
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CRKL is a 33kDa adaptor protein which has been shown to activate the RAS and JUN kinase signalling pathways and transforms fibroblasts in a RAS dependent manner. CRKL is a substitute of BCR ABL tyrosine kinase. In addition, CRKL has oncogenic potential. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7925-10D
Reactivities: Human, Mouse
Hosts: Goat
Applications: ELISA, Western Blot
Size: 1mg
Form: Supplied as a liquid in Tris-saline, pH 7.2. 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Crk like protein, Crkol, HGNC:2363, Oncogene CrkL, V crk Avian sarcoma virus CT10 oncogeneomolog like, V crk sarcoma virus CT10 oncogene homolog avian like
References: Senechal K et al. The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene. J Biol Chem 271:23255-61 (1996). PubMed: 8798523. Search PubMed (MEDLINE) for references to CrkL
Additional info: Species Crossreactivity: Reacts with Human and Mouse.

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