Cu/Zn SOD (human) Polyclonal Antibody

Antigen: human Cu/Zn SOD . Host: rabbit . Cross Reactivity: (+) human, mouse, bovine, monkey, coral, canine, hamster, porcine, rabbit, ovine, and rat Cu/Zn SOD . Applications: EIA, IHC, IP, and WB . SOD1 contains Cu and Zn ions as a homodimer and exists in the cytoplasm where it plays a major role in antioxidant defense mechanisms by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2.

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SPECIFICATIONS

Catalog Number

10011388

Applications

IHC, IP, WB

Hosts

Rabbit

Form

100 microL

P Type

Antibodies

Purity

23 kDa

Weight

0

Antigen

human Cu/Zn SOD

Storage Temp

-20

Shipping Temp

-20

Additional Info

Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body. It works by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase. In general, SODs play a major role in antioxidant defense mechanisms. There are two main types of SOD in mammalian cells. One form, SOD1, contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cystines forming an intra-subunit disulphide bridge. The second form, SOD2, is a manganese-containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form, SOD3 or EC-SOD, is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDa and it exists only in the extra-cellular space. SOD3 can also be distinguished by its heparin-binding capacity.