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CXCR4 (Fusin, LESTR, HUMSTR, C-X-C Chemokine Receptor 4, CD184)

CXCR4 (Fusin, LESTR, HUMSTR, C-X-C Chemokine Receptor 4, CD184)

Cat no: C8375-01C

Supplier: United States Biological
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Cellular Localization: Cell Membrane Positive Control: Human peripheral blood cells or sections of human spleen cells. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry (paraffin-embedded sections) and Immunocytochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C8375-01C
Reactivities: Human
Hosts: Goat
Applications: ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ug
Form: PBS, 1mg/ml BSA, 0.1% sodium azide, pH7.2
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: CD184, Chemokine CXC Motif Receptor 4, FB22, Fusin, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3, NPYY3R, Probable G protein coupled receptor lcr1 homolog, WHIM
References: This product has been used in:Bleul CC et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382:829-33 (1996). Loetscher M et al. Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. J Biol Chem 269:232-7 (1994). 3. Schimanski, C.C., et al. Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer. Clin. Cancer Res. 11(5):1743-1750, 2005.
Additional info: Peptide sequence is < 50% identical to other human chemokine receptors in this regionall Species Crossreactivity: Crossreacts with Human.

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