CXCR5 (C-X-C Chemokine Receptor 5)

Cat no: C8375-10A

Supplier: United States Biological

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This gene was identified as a gene specifically expressed in Burkitt's lymphoma and lymphatic tissues. The protein encoded by this gene is predicted to be a seven transmembrane G protein- coupled receptor and belongs to the CXC chemokine receptor family. BLC, a B-lymphocyte chemoattractant, was identified to be a specific ligand for this receptor. Studies of this gene and its mouse conterpart strongly suggest the essential function of this gene in B cell migration and localization within specific anatomic compartments, such as follicles in lymph nodes as well as in spleen. Two alternatively spliced variants of this gene exist. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 10-25mg/ml for 10e5 cells. Using human peripheral blood mononuclear cells expressing CXCR5. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	C8375-10A
Reactivities:	Human
Hosts:	Mouse
Applications:	Flow Cytometry
Size:	100ug
Form:	Supplied as a liquid in PBS. No preservative.
P type:	Mab
Isotype:	IgG2b
Purity:	Purified by Protein G affinity chromatography.
References:	1. Wells TN et al. Definition, function and pathophysiological significance of chemokine receptors. Trends Pharmacol Sci 19:376-80 (1998). . 2. Gunn MD et al. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature 391:799-803 (1998). . 3. Forster R et al. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87:1037-47 (1996).
Additional info:	Recognizes human CXCR5 (BLR1) transfected cells but not with the parent cell line by Flow Cytometry. Shows no crossreactivity with human CXCR2, CXCR3 and CXCR4.

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CXCR5 (C-X-C Chemokine Receptor 5)

Cat no: C8375-10A

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