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Cyclin B1, CT

Cat no: C8453A

Cyclin B1, CT

Cyclin B1 regulates mitosis in conjunction with Cdc2 kinase to form the Cdc2-cyclin B1 complex also known as maturation promoting factor (MPF) (1-2). The activation of the complex begins when the regulatory subunit, cyclin B1, associates with the catalytic subunit of Cdc2. Cyclin B1 levels rise during S phase and G2, and peak at mitosis. The timing of mitosis can also be influenced by changes in cyclin B1

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SPECIFICATIONS

Catalog Number

C8453A

Size

100ul

Applications

FC, ICC, IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid

P Type

Mab

Purity

Supernatant

Isotype

IgG

References

1. Morgan, D.O.. 1997. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol. 13: 261-291 2. Dunphy, W.G.. 1994. The decision to enter mitosis. Trends Cell Biol. 4: 202-2073. Gallant, P., and E.A. Nigg. 1992. Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells. J. Cell Biol. 117: 213-224

Additional Info

Recognizes human cyclin B1

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