Cyclin C (Cyclin-C, SRB11 Homolog, hSRB11, CCNC)

Cyclin C was originally identified by a genetic screen for human and Drosophila cDNAs that complement a triple knock-out of the CLN genes in Saccharomyces cerevisiae. Cyclin C is a nuclear protein present in a multiprotein complex. It interacts both in vitro and in vivo with cdk8, a novel protein-kinase of the cdk family. It is suggested that cyclin C and cdk8 control RNA polymerase II function. Human cdk8-cyclin C might be functionally associated with the mammalian transcription apparatus, perhaps involved in relaying growth-regulatory signals.\n\nApplications:\nSuitable for use in Immunoprecipitation, Western Blot and Immunofluorescence. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 5ug/ml for 2h, RT\nImmunoprecipitation: 10ug/mg protein lysate\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHela cell, tonsils\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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