Home  >  Products  >  Cyclin D1, CT (CCND 1, CCND1, CCND1 Protein, B-cell CLL/lymphoma 1, B cell Leukemia 1, BCL1, BCL-1 Oncogene, D11S287E, G1/S-specific Cyclin D1, Parathyroid Adenomatosis 1, PRAD1, PRAD1 Oncogene, U21B31)
Cyclin D1, CT (CCND 1, CCND1, CCND1 Protein, B-cell CLL/lymphoma 1, B cell Leukemia 1, BCL1, BCL-1 Oncogene, D11S287E, G1/S-specific Cyclin D1, Parathyroid Adenomatosis 1, PRAD1, PRAD1 Oncogene, U21B31)

Cyclin D1, CT (CCND 1, CCND1, CCND1 Protein, B-cell CLL/lymphoma 1, B cell Leukemia 1, BCL1, BCL-1 Oncogene, D11S287E, G1/S-specific Cyclin D1, Parathyroid Adenomatosis 1, PRAD1, PRAD1 Oncogene, U21B31)

Cat no: C8454-01U

Supplier: United States Biological
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Regulated progression through the cell cycle requires sequential expression of a family of proteins called cyclins. Upon their induction, cyclins form complexes with specific cyclin-dependent kinases (CDKs), creating active holoenzymes that phosphorylate target proteins that are required for cell-cycle progression. Induction of the proto-oncogene cyclin D1, and its binding to CDK4 or CDK6, is a rate-limiting event during cell-cycle progression through G1 phase. Some studies suggested that cyclin D1 also has CDK-independent functions. Studies in zebrafish model showed that cyclin D1 is upregulated by meis1, and it controls several development processes and in some way, carcinogenesis. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Control Peptide: C8454-01W Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C8454-01U
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Fu, M., et al. (2004). Endocrinology 145, 5439-5447. 2. Bessa, J. et al. (2008).Development 135, 799-803
Additional info: Recognizes zebrafish Cyclin D1.

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