CysLT1 Receptor Polyclonal Antibody

Antigen: human CysLT1 receptor C-terminal amino acids 318-337 . Host: rabbit . Cross Reactivity: (+) human CysLT1 receptor . Application(s): FC, ICC, IHC (paraffin-embedded sections), and WB . The CysLT1 receptor binds LTD4, LTC4, and LTE4, playing a major role in asthma by facillitating airway and pulmonary vascular smooth muscle contraction, increased vascular permeability, and stimulating mucus secretion. The mRNA for the human CysLT1 receptor is expressed in spleen and peripheral blood leukocytes with smaller amounts in lung, placenta, and small intestine.

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SPECIFICATIONS

Catalog Number

120500

Applications

FC, ICC, IHC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Leukotrienes|Eicosanoids

Weight

0

Antigen

human CysLT1 receptor C-terminal amino acids 318-337 (YVPRKKASLPEKGEEICKV){7174}

Storage Temp

-20

Shipping Temp

-20

Additional Info

The cysteinyl leukotrienes (CysLTs; LTC4, LTD4, and LTE4) contract airway and pulmonary vascular smooth muscle, increase vascular permeability, and stimulate mucus secretion, thereby playing a major role in asthma. LTC4, LTD4, and LTE4 mediate their actions via at least two receptors designated CysLT1 and CysLT2. Cloning of the human CysLT1 receptor reveals it is a 337 amino acid protein with a calculated molecular mass of 38,549. The rank order of binding for leukotrienes to the cloned receptor, as determined using a radioligand binding assay, is LTD4 >> LTC4 = LTE4 >> LTB4. The mRNA for the human CysLT1 receptor is expressed in spleen and peripheral blood leukocytes with smaller amounts in lung, placenta, and small intestine. Immunohistochemical studies reveal the receptor is expressed on eosinophils, mast cells, macrophages, neutrophils, and vascular endothelial cells in the nasal mucosa.