CysLT2 Receptor (N-Term) Polyclonal Antibody

Antigen: human CysLT2 receptor N-terminal amino acids 1-18 . Host: rabbit . Cross Reactivity: (+) human CysLT2 receptor; (-) CysLT1 receptor, mouse, and rat CysLT2 receptors . Application(s): FC, ICC, IHC, and WB . The CysLT2 receptor binds LTD4, LTC4, and LTE4 playing a major role in asthma by facillitating airway and pulmonary vascular smooth muscle contraction, increased vascular permeability, and stimulating mucus secretion. The mRNA for the human CysLT2 receptor is expressed in lung macrophages, airway smooth muscle, cardiac Purkinje cells, adrenal medulla cells, peripheral blood leukocytes, spleen, placenta, and brain.

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SPECIFICATIONS

Catalog Number

120560

Applications

ELISA, FC, ICC, IHC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Leukotrienes|Eicosanoids

Weight

0

Antigen

human CysLT2 receptor N-terminal amino acids 1-18 (MERKFMSLQPSISVSEME){8519,9059}

Storage Temp

-20

Shipping Temp

-20

Additional Info

The cysteinyl leukotrienes (cysLTs) (LTC4, LTD4, and LTE4) contract airway and pulmonary vascular smooth muscle, increase vascular permeability and stimulate mucus secretion, thereby playing a major role in asthma. LTC4, LTD4, and LTE4 mediate their actions via at least 2 receptors designated CysLT1 and CysLT2. Cloning of the human CysLT2 receptor reveals it is a 346 amino acid protein with 38% homology to the human CysLT1 receptor. The rank order of binding for leukotrienes to the cloned receptor, as determined using a radioligand binding assay, is LTC4 = LTD4 >> LTE4. The mRNA for the human CysLT2 receptor is expressed in lung macrophages, airway smooth muscle, cardiac Purkinje cells, adrenal medulla cells, peripheral blood leukocytes, spleen, placenta, and brain.