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Products CysLT2 Receptor (N-Term) Polyclonal Antibody
| Catalogue number: | 120560 |
| Hosts: | Rabbit |
| Applications: | ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human CysLT2 receptor N-terminal amino acids 1-18 (MERKFMSLQPSISVSEME){8519,9059} |
| P type: | Antibodies|Leukotrienes|Eicosanoids |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | The cysteinyl leukotrienes (cysLTs) (LTC4, LTD4, and LTE4) contract airway and pulmonary vascular smooth muscle, increase vascular permeability and stimulate mucus secretion, thereby playing a major role in asthma. LTC4, LTD4, and LTE4 mediate their actions via at least 2 receptors designated CysLT1 and CysLT2. Cloning of the human CysLT2 receptor reveals it is a 346 amino acid protein with 38% homology to the human CysLT1 receptor. The rank order of binding for leukotrienes to the cloned receptor, as determined using a radioligand binding assay, is LTC4 = LTD4 >> LTE4. The mRNA for the human CysLT2 receptor is expressed in lung macrophages, airway smooth muscle, cardiac Purkinje cells, adrenal medulla cells, peripheral blood leukocytes, spleen, placenta, and brain. |
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