Cysteinyl Leukotriene EIA Kit

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid via the 5-lipoxygenase (5-LO) pathway in leukocytes. LTC4, LTD4, and LTE4 are collectively referred to as cysteinyl leukotrienes (CysLTs). LTC4 and LTD4 are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. The biological activity of LTE4 is much lower in most systems studied, but its presence reflects the prior existence of LTC4 and LTD4. Cayman's CysLT EIA Kit is a competitive assay based on a proprietary high-affinity monoclonal antibody that can be used for quantification of CysLT in urine and other sample matrices. The EIA typically displays an IC50 (50% B/B0) of approximately 103 pg/ml and a detection limit (80% B/B0) of approximately 34 pg/ml.

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SPECIFICATIONS

Catalog Number

500390

Form

96 Well

P Type

Assay Kits|Eicosanoids

Weight

0

Storage Temp

-80

Shipping Temp

-80

Additional Info

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid via the 5-lipoxygenase (5-LO) pathway in leukocytes. LTC4, LTD4, and LTE4 are collectively referred to as cysteinyl leukotrienes (CysLTs). LTC4 and LTD4 are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. The biological activity of LTE4 is much lower in most systems studied, but its presence reflects the prior existence of LTC4 and LTD4. Cayman's CysLT EIA Kit is a competitive assay based on a proprietary high-affinity monoclonal antibody that can be used for quantification of CysLT in urine and other sample matrices. The EIA typically displays an IC50 (50% B/B0) of approximately 103 pg/ml and a detection limit (80% B/B0) of approximately 34 pg/ml.