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Products Cysteinyl Leukotriene Express EIA Kit
| Catalogue number: | 10009291 |
| Weight: | 0 |
| Form: | 96 Well |
| P type: | Assay Kits|Leukotrienes|Eicosanoids |
| Shipping temp: | -80 |
| Storage temp: | -80 |
| Additional info: | Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid via the 5-lipoxygenase (5-LO) pathway in leukocytes. LTC4, LTD4, and LTE4 are collectively referred to as cysteinyl leukotrienes (CysLTs). LTC4 and LTD4 are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. The biological activity of LTE4 is much lower in most systems studied, but its presence reflects the prior existence of LTC4 and LTD4. Cayman's CysLT Express EIA Kit is a competitive assay that can be used for measurement of all three primary CysLTs in urine, culture media, and other sample matrices. The EIA typically displays an IC50 (50% B/B0) of approximately 80 pg/ml and a detection limit (80% B/B0) of approximately 20 pg/ml. This sensitive assay takes about three hours to complete. |
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