Cytokeratin 17

Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40kD and 68kD and isoelectric pH between 4.9 ? 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.\n\nApplications: \nSuitable for use in Western Blot and Immunohistochemistry (Fr) (paraffin-embedded sections). Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C9097-16C

Size

500ul

Applications

IHC, WB

Hosts

Mouse

Reactivities

Hum, Rat

Form

0.09% sodium azide

P Type

Mab

Purity

Tissue culture supernatant

Isotype

IgG2b

References

1. Troyanovsky, S.M. et al. (1989) J. Cell.Sci. 93:419-426.

Additional Info

This antibody recognizes the 46kD cytokeratin 17, expressed primarily by basal cells of complex epithelia, and with myoepithelial cells in salivary and sweat glands. In neoplastic tissues cytokeratin 17 is expressed by squamous cell carcinoma of the lung, cervix and buccal cavity. Species Crossreactivity: Crossreacts with Human and Rat.