Cytomegalovirus (CMV)

Cat no: C9011-01G

Supplier: United States Biological

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Human cytomegalovirus is a ubiquitous herpes virus. The primary infection usually occurs in childhood where it most often is asymptomatic. After initial exposure, the virus establishes a life-long infection. In neonates, and in immunocompromised individuals, such as AIDS patients and transplant recipients, HCMV can cause severe life-threatening infections, and it is the most common cause of viral birth defects. Antibody CCH2 reacts with an early nuclear protein identical with the non-structural DNA-binding protein p52. Antibody DDG9 reacts with an immediate early nuclear protein of about 76kD. For both antibodies, the reactivity persists also at later stages during the HCMV infection where the localization is less distinctly nuclear and appears to be in the cytoplasm. Laser confocal microscopy, however, shows that the reaction is limited to the nuclear membrane. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Paraffin): 1:10-1:25 Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher. Positive Control: Infected lung, human salivary gland Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	C9011-01G
Reactivities:	Human
Hosts:	Mouse
Applications:	Immunofluorescence, Immunohistochemistry, Western Blot
Size:	500ul
Form:	Supplied as a liquid, 0.05% sodium azide.
P type:	Mab
Isotype:	IgG2a+IgG1,k
Purity:	Supernatant
References:	1. Zweygberg et al. J Virol Methods 27: 211, 1990. 2. Leland et al. J Clin Microbiol 27: 1159, 1989. 3. Ashley et al. J Clin Microbiol 27: 2858, 1989. 4. Niedobitek et al. J Clin Pathol 41: 1005, 1988.
Additional info:	Recognizes human immediate early and early Cytomegalovirus at 76kD. Does not crossreact with adenovirus, herpes simplex virus, and varicella zoster virus.

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Cytomegalovirus (CMV)

Cat no: C9011-01G

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