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DCX (Doublecortin)

Cat no: 030140

DCX (Doublecortin)

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.\n\nApplications:\nWestern Blot: 1:500-1:2000\nImmunohistochemistry: 1:200-1:1000\nImmunocytochemistry: 1:200-1:1000\nFlow Cytometry: 1:200-1:400\nELISA: 1:10000\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

030140

Size

100ul

Applications

ELISA, FC, ICC, IHC, WB

Hosts

Mouse

Reactivities

Hum

Form

Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer\n<br>

P Type

Mab

Purity

Purified

Isotype

IgG1

References

1.FASEB J. 2009 Dec;23(12):4276-87. \n2.J Cell Biol. 2010 Nov 1;191(3):463-70.

Additional Info

Human

Alternative Names

DC; DBCN; LISX; SCLH; XLIS

Read more on Supplier website

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info
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