Cayman Chemical has partnered with (delta)Tm Technologies LLC to provide a rapid, sensitive, and economical method for assessing both protein stability and protein-ligand interactions using a Thermal Stability Assay (TSA). These proprietary formulations ensure accurate and reproducible data while minimizing the deleterious effects of increasing temperature and its impact on the experimental solutions. This technology can be used to optimize experimental conditions before proceeding to more extensive studies such as ITC, SPR, or crystallography. By using the Protein Stability QC Screening Kit, TSA will allow you to determine which pH and ionic strength give the largest change in Tm values. This positive change occurs as the protein, in its native state, is unfolded and intercalated with dye to give a new melting temperature value. (delta)Tm Technologies has introduced 72 unique conditions that cover all pHs and salt concentrations, eliminating any guesswork and providing you with answers.