Home  >  Products  >  Desmoglein 1 (Desmoglein-1, Desmosomal Glycoprotein 1, DG1, DGI, DSG1, DSG, Cadherin Family Member 4, CDHF4, Pemphigus Foliaceus Antigen, PPKS1, SPPK1)
Desmoglein 1 (Desmoglein-1, Desmosomal Glycoprotein 1, DG1, DGI, DSG1, DSG, Cadherin Family Member 4, CDHF4, Pemphigus Foliaceus Antigen, PPKS1, SPPK1)

Desmoglein 1 (Desmoglein-1, Desmosomal Glycoprotein 1, DG1, DGI, DSG1, DSG, Cadherin Family Member 4, CDHF4, Pemphigus Foliaceus Antigen, PPKS1, SPPK1)

Cat no: D3221-82D

Supplier: United States Biological
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Desmoglein 1 is a member of the desmosomal cadherin family that comprise the desmogleins and desmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link the intermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity. Applications: Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunofluorescence: 1:10 Western Blot: 1:10 Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D3221-82D
Reactivities: Human
Hosts: Mouse
Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Wahl, J et al; Generation of monoclonal antibodies specific for desmoglein family members. Hybrid Hybridomics 2002, 21: 37.
Additional info: Recognizes human desmoglein 1 at ~165kD. Does not cross react with desmoglein 2 or desmoglein 3.

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