Home  >  Products  >  Desmoglein 2 (Desmoglein-2, DSG2, ARVC10, ARVD10, Cadherin Family Member 5, CDHF5, CMD1BB, HDGC, MGC117034, MGC117036, MGC117037)
Desmoglein 2 (Desmoglein-2, DSG2, ARVC10, ARVD10, Cadherin Family Member 5, CDHF5, CMD1BB, HDGC, MGC117034, MGC117036, MGC117037)

Desmoglein 2 (Desmoglein-2, DSG2, ARVC10, ARVD10, Cadherin Family Member 5, CDHF5, CMD1BB, HDGC, MGC117034, MGC117036, MGC117037)

Cat no: D3221-83F

Supplier: United States Biological
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Desmoglein 2 is a member of the desmosomal cadherin family that comprise the desmogleins and desmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link the intermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 2 is synthesized in the basal layers, depending on the certain types of epidermis. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Immunofluorescence: 1:10 Western Blot: 1:10 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D3221-83F
Reactivities: Human
Hosts: Mouse
Applications: Immunofluorescence, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Wahl, J., et al., Hybrid Hybridomics 21: 37 (2002). 2. Ota, T., et al., J. Dermatol. Sci. 32: 137 (2003). 3. Wahl, J., et al., J. Cell Sci. 109: 1143 (1996). 4. Lewis, J., et al., J. Cell Biol. 136: 919 (1997).
Additional info: Recognizes human desmoglein 2 at ~165kD. Does not crossreact with desmoglein 1 or desmoglein 3.

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