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DHEA (Dehydroepiandrosterone, Prasterone)

DHEA (Dehydroepiandrosterone, Prasterone)

Cat no: D3224-98C

Supplier: United States Biological
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DHEA is produced primarily by the adrenal glands, and together with its ester DHEA-sulphate (DHEAS), has been implicated in a wide range of physiological roles including aging, immunology, memory and obesity. In particular, DHEA and DHEAS differentially regulate growth-factor induced proliferation of chromaffin cells, and are thought to affect neurogenesis, neuronal survival, and neuronal stem cell proliferation. Blood measurements of DHEAS/DHEA are useful to detect excess adrenal activity due to adrenal cancer or hyperplasia, including certain forms of congenital adrenal hyperplasia. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:1,000-1:10,000 Optimal dilutions to be determined by the researcher. Recommended Secondary Antibodies: I1904-06C: IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo I1904-06H IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo I1904-14C: IgG, Fc (HRP) Pab Gt xMo Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D3224-98C
Hosts: Mouse
Applications: ELISA
Size: 200ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
Alternative names: 3b Hydroxy-5-androsten-17-one, 3b Hydroxyandrost-5-en-17-one, Androstenol, Androstenolone, Dehydroisoandrosterone, Hydroxyandrost-5-en-17-one, Trans Dehydroandrosterone
References: 1. Sicard, F. et al. (2007) Age-dependent regulation of chromaffin cell proliferation by growth factors, dehydroepiandrosterone (DHEA), and DHEA sulfate. Proc. Natl. Acad. Sci. USA. 104: 2007-2012.
Additional info: Recognizes Dehydroepiandrosterone.

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