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DP1 Receptor Polyclonal Antibody

Cat no: 101640

DP1 Receptor Polyclonal Antibody

Antigen: mouse DP1 receptor N-terminal amino acids 2-21 . Host: rabbit . Cross Reactivity: human, mouse, and rat DP1 receptors . Application(s): IHC and WB . DP1 receptor is one of two receptor isoforms for PGD2, a major COX metabolite of arachidonic acid. As a GPCR, the receptor primarily couples to Gs to increase cAMP, but also transiently increases Ca2+, apparently through the cAMP pathway

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SPECIFICATIONS

Catalog Number

101640

Applications

ICC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

mouse DP1 receptor N-terminal amino acids 2-21

Storage Temp

-20

Shipping Temp

-20

Additional Info

The DP1 receptor is one of two receptor isoforms for prostaglandin D2 (PGD2), a major cyclooxygenase metabolite of arachidonic acid. As a G-protein coupled receptor (GPCR), the receptor primarily couples to Gs to increase cAMP, but also transiently increases Ca2+, apparently through the cAMP pathway. DP1 receptor mRNA has been detected in various tissues and cells including brain, spleen, lung, bone marrow, stomach, skin, and mast cells, however little is know about its protein localization due to its low level of expression. Cayman's DP1 receptor polyclonal antibody detects the protein by western blot in samples such as cerebral cortex, hippocampus, and HT-29 cells, a colorectal cancer cell line shown to express this receptor. The antibody can also be used in immunocytochemistry/immunohistochemistry to detect DP1 receptor expression in cells and tissues.

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