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EHD2 (EH Domain Containing 2, PAST2)

EHD2 (EH Domain Containing 2, PAST2)

Cat no: E2215-80C

Supplier: United States Biological
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This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:32,000 Western Blot: 0.003-0.1ug/ml ~ 60kD band observed in Human Heart lysates (calculated MW of 61.2kD according to NP_055416.2). In transfected HEK293 transiently expressing EHD2 a band of approx. 62kD is observed. This band is not observed in the non-transfected HEK293. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E2215-80C
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: FLJ96617, EH domain containing 2, EH-domain containing 2, PAST2, EHD2
References: 1. Doherty KR, Demonbreun AR, Wallace GQ, Cave A, Posey AD, Heretis K, Pytel P, McNally EM. The endocytic recycling protein EHD2 interacts with myoferlin to regulate myoblast fusion. J Biol Chem. 2008 Jul 18;283(29):20252-60
Additional info: Recognizes human EHD2. Species sequence homology: mouse, rat, canine, bovine. This antibody is expected to recognise EHD1 protein as well as EHD2.

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