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eNOS Polyclonal Antiserum

Cat no: 160880

eNOS Polyclonal Antiserum

Antigen: human eNOS amino acids 1186-1203 . Host: rabbit . Cross Reactivity: (+) bovine and human eNOS; (-) iNOS and nNOS . Application(s): IP and WB . eNOS catalyzes the formation of NO from L-arginine in many cell types including vascular endothelium, bronchiolar epithelium, cardiac myocytes, spleen, and kidney.

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SPECIFICATIONS

Catalog Number

160880

Applications

IP, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

human eNOS amino acids 1186-1203 (RGAVPWAFDPPGSDTNSP){2667,3438,1902}

Storage Temp

-20

Shipping Temp

-20

Additional Info

eNOS catalyzes the formation of NO from L-arginine in many cell types including vascular endothelium, bronchiolar epithelium, cardiac myocytes, spleen, and kidney. Although eNOS was initially characterized as a constitutive enzyme, expression of eNOS mRNA is altered by many factors including shear stress, fibroblast growth factor, hypoxia, and LPS. eNOS is myristoylated and palmitoylated at the N-terminus, modifications which are required for localization to the plasmalalemmal caveolae of endothelial cells. Additionally, eNOS is phosphorylated on Ser1179 by protein kinase Akt resulting in an increase in NOS activity.

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