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Products eNOS Polyclonal Antiserum
| Catalogue number: | 160880 |
| Hosts: | Rabbit |
| Applications: | Immunoprecipitation, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human eNOS amino acids 1186-1203 (RGAVPWAFDPPGSDTNSP){2667,3438,1902} |
| P type: | Antibodies |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | eNOS catalyzes the formation of NO from L-arginine in many cell types including vascular endothelium, bronchiolar epithelium, cardiac myocytes, spleen, and kidney. Although eNOS was initially characterized as a constitutive enzyme, expression of eNOS mRNA is altered by many factors including shear stress, fibroblast growth factor, hypoxia, and LPS. eNOS is myristoylated and palmitoylated at the N-terminus, modifications which are required for localization to the plasmalalemmal caveolae of endothelial cells. Additionally, eNOS is phosphorylated on Ser1179 by protein kinase Akt resulting in an increase in NOS activity. |
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