Eotaxin 2 (MPIF-2,Myeloid progenitor inhibitory factor-2, Chemokine-beta-6, Ck-beta-6, SCYA24, small inducible cytokine A24, CCL24)

This protein of 78 amino acids belongs to the group of cytokines known as CC-Chemokines. Eotaxin-2 is identical with MPIF-2 (Myeloid progenitor inhibitory factor-2) and is known also as Chemokine-beta-6 (abbr. Ck-beta-6). The new designation is SCYA24 [small inducible cytokine A24]. The factor has been renamed CCL24. See also: SCY family of cytokines for a systematic nomenclature. The eotaxin-2 and eotaxin-3 genes are located within a region of approximately 40 kilobases on human chromosome 7q11.23.\n\nThree variants of 73, 75, and 76 residues truncated at the C-terminus have been described also. The protein is distantly related to, but functionally very similar, to Eotaxin. Murine eotaxin-2 appears to be produced constitutively in the jejunum and spleen. Production is induced by allergen challenge and IL4 overexpression (Zimmermann et al, 2000).\n\nEotaxin-2 induces chemotaxis of eosinophils and basophils, and the release of histamine and leukotriene C-4 from basophils primed with IL3. Eotaxin-2 activates chemotaxis-related events such as actin polymerization, and the respiratory burst almost as efficiently as Eotaxin. Monoclonal antibodies (7B11) selectively blocking the eotaxin receptor, CCR3, also block migration and release responses. Intradermal injection of eotaxin-2 in a rhesus monkey (100 or 1,000 pmol per site) induces a marked local infiltration of eosinophils.\n\nApplications:

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SPECIFICATIONS

Catalog Number

E3351-07A

Size

500ug

Applications

ELISA

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. No preservative added.

P Type

Mab

Purity

Puri?ed from ascites ?uid followed by Protein A af?nity chromatography.

Isotype

IgG1,k

References

Elsner J et al Eotaxin-2 activates chemotaxis-related events and release of reactive oxygen species via pertussis toxin-sensitive G proteins in human eosinophils. European Journal of Immunology 28(7): 2152-2158 (1998); Forssmann U et al Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. Journal of Experimental Medicine 185(12): 2171-2176 (1997); Kitaura M et al Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. Journal of Biological Chemistry 274(39): 27975-27980 (1999); White JR et al Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. Journal of Leukocyte Biology 62(5): 667-675 (1997); Zimmermann N et al Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen challenge and IL4 overexpression. Journal of Immunology 165(10): 5839-5846 (2000)

Additional Info

Eotaxin-2