EP2 Receptor Polyclonal Antibody

Antigen: synthetic peptide from human EP2 receptor C-terminal amino acids 335-358 . Host: rabbit . Cross Reactivity: (+) human, mouse, and rat EP2 receptors; (-) EP1, EP3, and EP4 receptors . Application(s): ICC and WB . Binding of PGE2 to the EP2 receptor results in an increase in adenylate cyclase activity with a subsequent increase in cAMP. Pharmacologicially, EP2 receptors mediate relaxation of smooth muscle and are distinguished from EP4 receptors by their sensitivity to the EP2 receptor selective agonist butaprost

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SPECIFICATIONS

Catalog Number

101750

Applications

ICC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Eicosanoids

Weight

0

Antigen

synthetic peptide from human EP2 receptor C-terminal amino acids 335-358{3178}

Storage Temp

-20

Shipping Temp

-20

Additional Info

The biological effects of prostaglandin E2 (PGE2) are mediated through interaction with four distinct membrane-bound G-protein coupled EP receptors: EP1, EP2, EP3, and EP4. Binding of PGE2 to the EP2 receptor results in an increase in adenylate cyclase activity with a subsequent increase in cAMP. Pharmacologicially, EP2 receptors mediate relaxation of smooth muscle and are distinguished from EP4 receptors by their sensitivity to the EP2 receptor selective agonist butaprost. The human EP2 receptor is comprised of 358 amino acids with a molecular mass of approximately 40,000. A band at 53 kDa is detected in most samples by Western blotting. mRNA for the EP2 receptor is expressed in a variety of tissues including lung, placenta, spleen, intestine, kidney, and sensory neuron.